This research communication reports a computational study of mixed convection towards a stretched surface with a Carreau-Yasuda model (non-Newtonian fluid). A Carreau-Yasuda model, acceptable for numerous non-Newtonian models, is utilized to illustrate the behavior of both shear thinking and thinning liquids. The energy and concentration equations are developed using the concept of law of conservations of energy and mass in the presence of thermal radiation, Soret and Dufour effects, viscous dissipation and activation energy. Total entropy rate depends on four different types of irreversibilities, i.e., thermal, Joule heating, fluid friction, mass and calculated through second law of thermodynamics. Convective boundary conditions is imposed at the boundary for both heat and mass transport. The governing equations are transformed into ordinary ones via appropriate similarity transformations and numerical results are obtained through Built-in-Shooting method. The pertinent flow parameters for the problem are mixed convection parameter, Soret and Dufour parameters and activation parameter. The impact to the constitutive non-Newtonian fluid (Carreau-Yasuda model) on the velocity, temperature,
concentration, entropy generation rate, skin friction and heat transfer rate is discussed in detail.
The obtained results are compared with previous published research articles and good agreement
is found. The results reveal that temperature increases against higher values of Dufour parameters.